Top Ten Myths of Container Closure Integrity Testing

Three decades ago, testing a container closure system for integrity meant performing a product sterility test. As recently as ten years ago, container closure integrity testing (CCIT) meant microbial challenge tests, or in more progressive circles, dye ingress tests. Advances in package leak testing technology and shared research studies present a new opportunity to redefine CCIT. The following is intended to dispel some of the more popular CCIT misconceptions.

Pharmaceutical Container/Closure Integrity II

Pharmaceutical Container/Closure Integrity II: The Relationship Between Microbial Ingress and Helium Leak Rates in Rubber-Stoppered Glass Vials